Genomics and Genetics Weekly

HIV/AIDS Pathogenesis - Incubation period of acute retroviral syndrome is a multistep process

HIV/AIDS Research - Constrained "molecular tongs" designed to dissociate HIV-1 protease dimer

HIV/AIDS Research - HIV-1 Nef produces survival signals through Erk-mediated Bcl-X-L induction

HIV/AIDS Research - HIV-1-RT Gln145Met/leu change confer drug resistance/impair virus replication

HIV/AIDS Research - Parallel tempering method predicts HIV accessory protein structure

HIV/AIDS Research - Researchers' findings advance HIV/AIDS research

HIV/AIDS Research - Researchers' work adds to HIV/AIDS body of knowledge

HIV/AIDS Treatment - Metabolic abnormalities less with atazanavir than with other protease inhibitors

Hantavirus Pulmonary Syndrome - 3 genotypes associated with hantavirus pulmonary syndrome circulating in Yuto

Haplotyping - Map of human genetic variation will speed search for disease genes

Helicobacter Pylori -  H. pylori-induced spermine oxidation results in apoptosis and DNA damage

Helicobacter Vaccine - Immune cells from Helicobacter-immune mice produce more IFN-gamma

Hematopoiesis - MII-dependent Hox program drives hematopoietic progenitor expansion

Hemodialysis - Biocompatible membranes minimize the biflammatory response in hemodialysis

Hepatitis C Therapy - PEGASYS combination therapy approved for hepatitis C/HIV coinfection in Europe

Hepatoblastoma - Conductin is a direct target gene of WNT signaling hepatoblastomas

Histones - Cse4 histone analyzed, role of domain in yeast centromere revealed

Hormones - Striatin is scaffold for estrogen-mediated activation of signaling pathways

Hypertension - Angiotensin II type 2 receptor protects the hearts of hypertensive mice

Hypertension - Common allelic variation may affect development of CV disease traits

Hypertension - High blood pressure in African Americans linked to two genomic regions

Hypertension - Human data on next generation of renin inhibitors for hypertension announced

Immunology - Most LPS-induced macrophage gene expression is MyD88-independent

Immunology - Role of CD40 signaling in germinal center development clarified

Immuontherapy - Grouper/mullet iridovirus bears genetic and antigenic similarities to RSIV

Information Technology - Online forum aims to improve New York health care quality

Insulin Resistance - Insulin resistance caused by change in CD36 expression

Kaposi Sarcoma-Associated Herpesvirus - Cidofovir used to provide insight into KSHV replication and pathogenesis

Klebsiella Pneumoniae -  K. pneumoniae outbreak produces new carbapenern hydrolyzing beta-lactamase

Legal Issues - Ruling that embryo is a person could have chilling effect

Leukemia - Recent findings in leukemia described

Licensing - Drug company acquires license for hyperphosphatemia treatment from Altair

Licensing - Exclusive license granted to commercialize gene mapping, analysis technology

Licensing - Genetics company grants license to Australian Genome Research Facility

Lipid Studies - Endothelial lipase can promote monocyte adhesion to the vascular endothelium

Listeria Monocytogenes -  L. monocytogenes sigma(B) needed for stress-response induction in GI passage

Liver Cancer - Hepatitis C virus core protein encoded in hepatocellular carcinomas

Liver Cancer - Researchers report details of new studies and findings in the area of liver cancer

Malaria - Malaria is a multi-faceted disorder

Malaria - P-opiate receptors or endogenous opiods may affect chloroquine itching

Medicare - Disease management service company reaches patient recruitment goal for Medicare

Melanoma - Findings advance knowledge in melanoma research

Melanoma - Tissue microarrays used to analyze expression of DNA mismatch-repair genes

Menopause - Follitropin receptor knockout mice model women's age-related changes

Mental Health - Gene variants associate with aggression in male patients with schizophrenia

Mental Health - Neuregulin genotype directs the way schizophrenia responds to medication

Mental Health - Study shows playing a musical instrument reverses stress on the genomic level

Metabolic Syndrome - Studies add new findings to metabolic syndrome body of knowledge

Movement Disorders - Magnetic resonance images guide genetic tests for nemaline myopathy

Multiple Myeloma - Companies advance PXD101 into phase II clinical program

Multiple Sclerosis - Genetic variant may explain why women develop MS more than men

Muscular Dystrophy - Orphan drug designation granted to PTC124 for Duchenne muscular dystrophy

Neural Stem Cell Research - NSCs isolated from embryonic forebrain & induced into oligodendrocyte precursors

Neurodegeneration - BAG5 studied, effects on parkin and dopaminergic neuron degeneration revealed

Neurodegenerative Disease - Cerebrospinal fluid protein patterns in neurodegenerative disease revealed

Neurology - Fragile X mental retardation studied, necessity of specific protein shown

Neurology - Shank3 analyzed, role in signaling and biological function demonstrated

Neurology - Zif268 expression is interwoven with neuronal plasticity

Neuromuscular Disease - Caveolin-3 deficiency causes limb-girdle muscular dystrophy type 1C

Neuromuscular Disease - Microdystrophin gene transfer recovers contractile ability in transgenic mice

Neuromuscular Disease - RYR1-related congenital myopathies depict common pathologies

Neuroprotection - Echinacoside rescues neuroblastoma cells from TNF alpha-induced apoptosis

Neuroscience - Methylenetetrahydrofolate reductase gene variants trigger essential tremor

Neuroscience - Mutant huntingtin gene thwarts cannabinoid receptor transcription

Neuroscience - Non-viral gene knockdown may treat neurological and psychiatric disorders

Neuroscience - Recent findings in neuroscience provide new insights

Neuroscience - Survival motor neuron constructs benefit spinal muscular atrophy models

Neuroscience - Virus-mediated parkin delivery prevents dopaminergic degeneration in mice

Nociception - Emotional reactivity involved in gender differences in pain sensitivity

Nosocomial Infection - U.K.'s MRSA problem is in the genes

Obesity - Genetics research unlocks a key regulator of weight in women

Obstetrics - Future of tocolytics in preterm labor questioned

Obstetrics - Study finds markers for premature birth risk at the molecular level

Oncogenesis - Findings in oncogenesis provide new insights

Oncogenesis - Recent findings in oncogenesis described

Oncology - Microarray discerns DNA changes in microdissected ovarian cancer specimens

Oncology - Ras oncogene promotes hypoxia-inducible factor-1alpha-related tumor growth

Oncology - Taxol induces caspase-10-dependent apoptosis

Ovarian Cancer - Endometrioid carcinomas have lower MIS rate and PTEN changes than uterine type

Parasitology - DNA microarrays suitable for analysis of T. cruzi gene expression

Parkinson Disease - Foundation boosts research in Parkinson and awards nearly $1 million in funding

Parkinson Disease - Parkin analyzed, role in increased dopamine uptake clarified

Patents - Company gets additional patent for its GeneXpert sample preparation cartridge

Patents - Japanese office issues patent certificate for NanoCrystal Technology

Pediatric Oncology - BRAF gene hotspot mutations not associated with pediatric solid neoplasms

Peptide Receptors - Guanylyl cyclase B receptor analyzed, critical reproductive roles revealed

Personnel - Cancer-focused biopharmaceutical company appoints 2 to development positions

Personnel - Company names chairman of board, chief operating officer

Personnel - Genome-based antibiotics developer names Thomas R. Parr chief scientific officer

Personnel - Pharma development company adds members to board of directors

Personnel - Pharmaceutical company adds member to board

Personnel - Protein therapeutics company announces executive appointments, new building

Phosphorylation - Kappa kinase beta species studied, serine phosphorylation demonstrated

Physiology - Inward-rectifier K channels analyzed, conductance determinants clarified

Polycystic Ovary Syndrome - Beta-cell dysfunction may be a key determinant of PCOS

Preventive Medicine - Triedix changes name to reflect baby boomer's demand for preventive healthcare

Product Licensing - Cardiovascular drug discovery company acquires cholesterol-lowering technology

Product Licensing - Company obtains license to patent linking genetics to cardiac arrhythmias

Product Licensing - GlaxoSmithKline licenses MetaBase

Product Licensing - Pharma companies sign license agreement for ADP receptor antagonist program

Prostate Cancer - Fibroblast growth factor 17 over-expressed in prostate cancer

Prostate Cancer - New agents being developed for prostate cancer prevention

Prostate Cancer - Prostate tumor progression may reflect aberrant DNA repair

Proteomics - FRS2alpha analyzed, role in induction of lens and retina revealed

Proteomics - Newly detected retinoid X receptor splice variants harbor unique properties

Proteomics - Soluble TWEAK protein generates highly vascularized tumors

Psychosis - mGlu2/3 receptor agonist studied, influence on neuronal injury clarified

RNA Polymerase - Bacteriophage T4 studied, binding of RNA polymerase domain by coactivator shown

RNA Research - Yeast mRNA-capping enzyme studied, different modes of ligand binding evident

Respiratory Medicine - Expiratory rates in chronic obstructive pulmonary disease link to select genes

Rheumatology - A key polymorphism of the CTLA-4 gene is not linked to rheumatoid arthritis

Rotovirus - Non-group A/B/C adult rotavirus cloned from gastroenteritis outbreak strain.

Russell-Silver Syndrome - Molecular screening detects maternal uniparental disomy of chromosome 7

Septic Shock - Using bosentan during the later stages of septic shock: a promising strategy

Serum Amyloid - Serum amyloid activating factor studied, transcriptional regulation revealed

Sex Steroids - Sex steroids reduce DNasel accessibility of androgen receptor promoter in brain

Sexual and Reproductive Health - Erectile dysfunction retreats in aging animals that receive gene therapy

Sexual and Reproductive Health - Germ cells are the chief producers of htCREB transcripts

Sexual and Reproductive Health - Supplemental NDA confirmed for lasofoxifene as a treatment for vaginal atrophy

Sleep Apnea - Study explored association of ACE polymorphism with sleep-disordered breathing

Stem Cell Research - Bill would endorse stem cell research, prohibit human cloning

Stem Cell Research - Differential gene expression characterized in stroma of giant cell bone tumor

Stem Cell Research - Immortalized otocyst cell lines study early stages of inner ear development

Stem Cell Research - Retroviral transduction augments the selection of modified stem cells

Stem Cell Research - SOX9 gene is key regulator of cartilage link protein

Stem Cell Research - Skeletal muscle satellite cells spontaneously enter alternative mesenchymal path

Stem Cell Research - Wnt 3a promotes proliferation and suppresses osteogenic differentiation of MSCs

Stem Cell Research - Writ signaling elicits multiple functions in stem cells

Stem Cell Transplantation - qPCR to monitor adenovirus after transplant useful for fatal disease prevention

Stem Cells Research - BM-derived SC fused with striated muscle not sufficient to activate muscle genes

Streptococcus -  S. equi subsp ruminatorum subsp nov. identified in small ruminants

Stress - Telomere shortening is accelerated in women in response to life stress

Surgical Technology - Medical device company completes launch of TAXUS Liberte

Synapsin - Excitatory and inhibitory synapses studied, roles of synapsins clarified

Testicular Cancer - Minimum genomic regions of imbalance involved in germ cell tumors determined

Thyroid Microcarcinoma - BRAF(T1796A) transversion prevalent mutational event in thyroid microcarcinoma

Transplant Medicine - 'Little Miracle' loses battle after infection

Transplant Medicine - Circles of DNA might help predict success of stem cell transplantation

Transplant Medicine - Committee endorses bill to give Arkansas organ donors a tax break

Transplant Medicine - Cytokine genotypes place renal allograft patients at risk for graft rejection

Transplant Medicine - Immunology company announces bone marrow transplant trial

Tularemia Vaccines - Reports describe recent advances in tularemia vaccines research

Type 2 Diabetes Treatment - U.S. FDA grants final approval for generic drug treatment for type 2 diabetes

Tyrosine Kinase - RNA-binding of SLM-1 and SLM-2 analyzed, nature of inhibition clarified

Urology - Mechanical stretch regulates gene expression in human bladder muscle cells

Venous Thromboembolism - Long-term anticoagulation is effective in patients with venous thromboembolism

Virology - Hepatitis B virus variants persist despite the lack of a core promoter

Virology - Hepatitis C virus IRES RNA coordinates translation-associated interactions

Virology - Respiratory syncytial virus studied, role in proinflammatory response revealed

Wilms Tumor - Beta-catenin target gene in WT1-mutant Wilms tumor identified