Published in Genomics and Genetics Weekly, March 4th, 2005
According to scientists in the United States, "In epidemiologic studies and disease prevention trials, interest often involves estimation of the relationship between some disease endpoints and individual exposure. In some studies, due to the rarity of the disease and the cost in collecting the exposure information for the entire cohort, a case-cohort design, which consists of a small random sample of the whole cohort and all the diseased subjects, is often used. Previous work has focused on analyzing data from the case-cohort design and few have discussed the sample size...
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