Immunology

Most LPS-induced macrophage gene expression is MyD88-independent

Published in Genomics and Genetics Weekly, March 4th, 2005

Contrary to conventional wisdom, most LPS-induced changes in macrophage gene expression occur independently of MyD88.

"Myeloid differentiation protein-88 (MyD88) is a signal adaptor protein required for cytokine production following engagement of Toll-like receptors (TLRs) by their cognate ligands," scientists in the United States explained. "Activation of both TLR-3 and TLR-4, however, can engage signaling events independent of MyD88 expression."

"The relative importance of these MyD88-dependent and -independent signaling pathways in the macrophage response to lipopolysaccharide (LPS) is unknown," noted H. Bjorkbacka and colleagues at Massachusetts...

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Source: Genomics and Genetics Weekly (2005-03-04)

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