Pediatric Neurology
Genes in the neonatal brain respond rapidly to ischemic injury
Published in Genomics and Genetics Weekly, March 4th, 2005
According to a study from Sweden, "ischemia induces a complex response of differentially expressed genes in the brain. In order to understand the specific mechanisms of injury in the developing brain, it is important to obtain information on global changes in the transcriptome after neonatal hypoxia-ischemia."
"In this study, oligonucleotide arrays were used to investigate genomic changes at 2, 8, 24 and 72 hours after neonatal hypoxia-ischemia, which was induced in 9-day-old mice by left carotid artery ligation followed by hypoxia (10% O2 )," wrote M. Hedtjarn and colleagues,...
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