Published in Genomics and Genetics Weekly, March 11th, 2005
"Peroxisome proliferator-activated receptor (PPAR) isoforms, alpha, gamma, and beta/delta, function as important lipid sensors as well as key regulators of energy homeostasis. PPAR-alpha plays a dynamic role in energy combustion by transcriptionally upregulating fatty acid oxidation systems primarily in liver, whereas PPAR-gamma functions as a regulator of adipogenesis and lipid storage. Overexpression of PPAR-gamma, using adenoviral expression approach, in PPAR-alpha-deficient mouse liver results in hepatic steatosis with concurrent expression of adipocyte specific genes,"...
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