Coronary Heart Disease

Studies have investigated genetic variants and response to statin therapy

Published in Genomics and Genetics Weekly, March 11th, 2005

A recent report on the pharmacogenetics of HMG-CoA reductase inhibitors explored the potential for genotype-based individualization of coronary heart disease management.

According to the report from Japan, "Despite the benefit of statin therapy in the prevention of coronary heart disease, a considerable inter-individual variation exists in its response. It is well recognized that genetic variation can contribute to differences in drug disposition and, consequently, clinical efficacy at the population level. Pharmacogenetics, exploring genetic polymorphisms that influence response to drug therapy, may one day allow the clinician to customize treatment strategies for...

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Source: Genomics and Genetics Weekly (2005-03-11)

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