Genomics and Genetics Weekly

Glutamate Receptor - Ionotrophic glutamate receptor sequences analyzed, interactions modeled

Growth Hormone Deficiency - Generic-drug company and Savient launch pediatric growth hormone treatment

HIV/AIDS Diagnostics - Rapid HIV test available in over-the-counter market

HIV/AIDS Drug Resistance - Certain HIV-1 resistance-associated mutations are highly stable

HIV/AIDS Drug Resistance - NRTIs may have continued anti-HIV-1 activity despite presence of resistance

HIV/AIDS Epidemiology - HIV-1 genetically diverse in rural eastern Cameroon

HIV/AIDS Pathogenesis - HIV-1 Nef does not significantly affect viral infectivity in target cells

HIV/AIDS Pathogenesis - HIV-1 Nef promotes physical interaction between endogenous AP-1 and MHC-I

HIV/AIDS Pathogenesis - Oligomerization required for HIV-1 Nef-induced Hck activation

HIV/AIDS Pathogenesis - Perlecan mediates cellular uptake of HIV-1 Tat

HIV/AIDS Pathogenesis - Research add new data to HIV/AIDS pathogenesis body of knowledge

HIV/AIDS Prognosis - HIV genotype/virtual phenotype predicts treatment outcome same as real phenotype

HIV/AIDS Research - Cell lines with an integrated luciferase gene determine HIV-1 infectivity

HIV/AIDS Research - Closing of the fingers domain generates motor forces in HIV RT

HIV/AIDS Research - Researchers' data advance HIV/AIDS research

HIV/AIDS Testing - Study shows HIV diagnostics tools not reaching people who need them most

HIV/AIDS Therapy - Data released from study comparing Viread and Emtriva to Combivir

HIV/AIDS Therapy - HIV-focused biopharmaceutical company's CEO interview available on web site

HIV/AIDS Therapy - Nelfinavir induces adipocyte necrosis by oxidative stress

HIV/AIDS Therapy - Stavudine plus didanosine associated with decreased mitochondrial mass

Head and Neck Cancer - Cyclin D1 overexpression alone does not cause salivary gland cancer growth

Hearing Loss - When the brain, not the ears, goes hard of hearing

Heart Disease Risk Factors - RAGE gene polymorphisms not risk factors for heart disease

Hematology - Gene therapy offers hope for correcting hemophilia

Hepatocellular Carcinoma - DNA repair genes upregulated in cancer-related cirrhosis

Herpesvirus - Researchers report details of new studies and findings in the area of herpesvirus

Hypertension - Essential hypertension may be mildly influenced by the MTHFR C677T variant

Hypertension - Study sought to clarify mechanisms of reduced coronary flow reserve in HT

Insomnia - Biopharma company reports results of insomnia treatment trail

Intersex - Surgery may be hasty for unclear gender

Kidney Proteins - PDZ proteins in the kidney studied, differential localization revealed

Left Ventricular Hypertrophy - Polymorphisms involved in left ventricular hypertrophy identified

Leukemia - AML1-ETO C-terminal NcoR/SMRT-interacting region deletion induces leukemia

Leukemia - Gamida-Cell and Teva to develop and commercialize StemEx for leukemia

Leukemia - Generic drug company, Gamida-Cell to develop StemEx for treatment of leukemia

Leukemia - Genome-wide mouse study yields link to human leukemia

Leukemia - Recent findings in leukemia provide new insights

Licensing - Vertex Pharma licenses VX-944 to Avalon Pharma for cancer treatment

Liver Cancer - EU funding helps fight liver cancer

Liver Fibrosis - Computerized morphometry analyzes cirrhotic liver specimens

Lung Cancer - Research uncovers mechanism of resistance to targeted therapy

Lung Cancer Pathogenesis - Immortalized bronchial epithelial cells useful to study lung cancer pathogenesis

Malaria -  Plasmodium parasite is a "new" challenge for insect innate immunity

Melanoma - Genes identified expressing elevated melanoma metastatic variants

Mergers & Acquisitions - Agriculture company to acquire Emergent Genetics, Inc.

Mergers & Acquisitions - Anti-infective focused company, Panacos Pharmaceuticals schedule merger vote

Mergers & Acquisitions - Life-sciences supplier acquires Proligo Group to expand genomics research tools

Mutagenesis - A rare amelogenin gene mutation impairs gender identification

Myelodysplastic Syndromes - Clinical data from initial REVLIMID study reported in journal

Myogenesis - Short interfering RNA elucidates the role of S1P in myogenic differentiation

Neonatology - Research casts further doubt on newborn sex-assignment surgeries

Neonatology - Researcher calls for improved newborn screening

Neural Stem Cells Research - Radial glia give rise to adult neural stem cells in subventricular zone

Neurodegeneration - Quercetin protects against oxidative stress-induced neurodegeneration

Neurology - Huntingtin associated protein 1 regulates early postnatal feeding in mice

Neurology - Tbr-1/CASK complex target genes identified in neurons

Neuromuscular Disease - Gain of function mutations associate with myotonic dystrophy type 1

Neuroscience - Light chain gene delivery yields focused neural inhibition

Neuroscience - Nervous system genes in Homo sapiens evolved at an accelerated pace

Neuroscience - Relationship between 5-HT neurotransmission and BDNF expression clarified

Non-Small Cell Lung Cancer - Gene expression alterations in squamous NSCLCs identified

Obesity Genomics and Genetics - FOXC2 C-512T polymorphism associated with obesity and dyslipidemia

Obesity Genomics and Genetics - Tumor necrosis factor gene polymorphism linked to waist-hip ratio

Obesity Pathogenesis - Obesity pandemic reviewed

Obesity Pathogenesis - Regulation of ghrelin gene expression in stomach examined

Obesity Surgery - Gene variants and binge eating predict morbid obesity therapy outcome

Obesity and Diabetes - Data advance knowledge in obesity and diabetes research

Oncology - CagA structure variability may explain H. pylori-related diseases

Oncology - CpG oligonucleotide and rituximab combine to attack non-Hodgkin lymphoma

Oncology - Gene sets identify hepatitis B virus-related liver cancer

Oncology - Gene silencing curbs the growth of breast cancer cells

Oncology - Genomic stability of post-resection lung cancer specimens determined

Oncology - Reports add new data to oncology research

Oncology - Tumors flourish in the presence of von Hippel-Lindau inactivation

Ophthalmology - First case reported of presumed vertical transmission of Coats' disease

Oral Health -  Candida albicans infection alters gene expression in oral epithelial cells

Osteoarthritis - Enzyme restoration using gene delivery promotes cartilage repair

Osteoporosis - Lactose malabsorption may be related to bone fractures in old age

Osteoporosis - Within-family associations for spine BMD found at two gene haplotypes

Ovarian Cancer - Researchers investigate leptin as a possible endocrine regulator

Pancreatic Cancer - IFN-gamma polymorphisms correlate with duration of survival in pancreatic cancer

Pancreatic Cancer - Trial of pancreatic cancer did not meet primary endpoint

Patents - Patent granted for copolymer-1 for protection from neuronal degeneration

Perception - Differences in taste perception directly related to genetic variation

Personnel - Clinical reference lab head Harrington to step down, CEO search underway

Personnel - Medical manufacturer names vice president and medical director

Personnel - Pharmaceutical company adds to scientific resource board

Personnel - Pharmaceutical company names new chief financial officer

Personnel - Protein therapeutics-focused company expands management team

Personnel - THYMITAQ maker names new CEO

Pertussis Vaccines - Research in pertussis vaccines provides new insights

Pheromones - Fus3-regulated Tec1 degradation studied, role in yeast MAPK signaling revealed

Physiology - Splicing of U12-type introns analyzed, influence on mRNA decay revealed

Polycystic Ovary Syndrome - Family history of type 2 diabetes is risk factor for women with PCOS

Preimplantation Genetic Diagnosis - PGD is a reproductive option for carriers of hemophilia

Product Licensing - Agreement will bring fluorous separation technology to oligonucleotide synthesis

Product Licensing - New license agreement signed for single chain antibodies

Product Licensing - Pharmaceutical company acquires access to TrueClone Collection

Product Licensing - Pharmaceutical company licenses topical products for hair growth

Prostate Cancer - Data: Provenge significantly improves survival in advanced prostate cancer

Prostate Cancer - HOXB13 suppresses growth of prostate cancer cells

Prostate Cancer - Injectable hormonal therapy for advanced prostate cancer available in the U.S.

Prostate Cancer - Phase 2 monotherapy trial of polyketide treatment for prostate cancer initiated

Protein Export - Role of a poly(A)-binding protein and nuclease complex in protein export shown

Proteomics - A key protein of human fetal liver erythroid cells harbors unique gene motifs

Proteomics - Differentiated pericytes establish proangiogenic gene expression

Proteomics - Prokaryote homologues forge a bond with human mitochondrial proteins

Psoriasis - FDA approves NDA for treatment of corticosteroid for plaque type psoriasis

Pulmonary Medicine - A prostaglandin receptor gene confers asthma susceptibility

Pulmonary Medicine - Bead array assay screens for mutations associated with cystic fibrosis

Pulmonary Medicine - T-bet variant predicts patient response to asthma therapy

RNA Research - RNA loop-loop complexes analyzed, closed loop base pairs revealed

Recurrent Pregnancy Loss - Sperm aneuploidy plays role in recurrent first trimester spontaneous abortions

Recurrent Spontaneous Abortion - Male fetuses more likely to survive in allo-immune RSA

Renal Disease - Ex vivo decorin gene transfer halts renal extracellular matrix deposition

Rheumatoid Arthritis - CV risk factors should be looked for and treated in patients with early RA

Rheumatoid Arthritis - Entelos to co-develop rheumatoid arthritis therapies

SARS Coronavirus - SARS-CoV genome detected in nasopharyngeal aspirate and autopsy lung specimen

Severe Combined Immunodeficiency - Newborn screening could detect bubble boy illness early, save lives

Stem Cell Research - Caspase-3 crucial for osteogenic differentiation of BM stromal stem cells

Stem Cell Research - Clonal type I IFN-producing/DC precursors contained in lymphoid/myeloid SCs

Stem Cell Research - Ink4a/ARF links senescence and aging

Stem Cell Research - Letter of Intent filed with U.S. NIH for stem cell research center grant

Stem Cell Research - P63 mRNAs likely to be expressed in primordial germ cells during development

Stem Cell Research - Suits filed to invalidate California's $3 billion stem cell institute

Stem Cell Research - Telomerase activity/length measured in proliferating mesenchymal stem cells

Stem Cell Research - Young blood revives aging muscles, Stanford researchers find

Stem Cell Transplantation - Adrenomedullin and endothelin-1 stimulate cord blood stem cell expansion

Stem Cell Transplantation - Findings advance knowledge in stem cell transplantation research

Stroke - Candesartan antagonizes angiotensin receptor 1 to provide neuroprotection

Stroke - Technology company reports help for migraine sufferers

Testicular Cancer - NALP7 may be therapeutic target in testicular seminomas

Testosterone-Producing Cells - Progenitor cells of testosterone-producing Leydig cells revealed

Thrombocytopenia - Thrombocytopenia studied, therapeutic approach for minibody agonist shown

Tissue Engineering - Collagen-related proteins expressed in septal cartilage during dedifferentiation

Tissue Engineering - MSCs immunoprivileged & potentially useful for HLA-incompatible transplantation

Transplant Medicine - Circles of DNA might help predict success of stem cell transplantation

Tuberculosis - Recurrent tuberculosis in US/Canada mostly due to relapse with same strain

Twinkle Helicase - Twinkle is a new mitochondrial 5'-3' DNA helicase

UMP Kinase - Bacterial UMP kinase studied, cooperative behaviors indicated

Ubiquitin - Ubiquitin-like protein Hub1 studied, role in splicing clarified

Umbilical Cord Blood Transplantation - Umbilical cord stromal cells promising for cell-based therapies

Uremia - Review explores aspects of nutrition in hyperhomocysteinemia and uremia

Vector Development - Intrahepatic hydrodynamics-based gene delivery generates human protein

Virology - Hepatitis delta antigen facilitates chaperone activities

Virology - Interleukin-12 restores immune responses in chronic hepatitis C patients

Virology - RNA interference uses several pathways to block viral infection

Virology - Recent studies add new data to virology research

Water Treatment - Coagulation pretreatment influences protozoan cyst removal from water

Wilms Tumor - Adult nephroblastoma patients may carry WT1 germline mutations

Xeroderma Pigmentosum - In world without sun, life revolves around ill daughter