Published in Genomics and Genetics Weekly, March 18th, 2005
According to recent research from the United States, "Coronary artery disease (CAD), including its most serious complication myocardial infarction (MI), is the leading cause of death in the U.S. and developed countries. We recently discovered that a seven-amino acid deletion in MEF2A, a transcription factor with a high level of expression in the endothelium of coronary arteries, cosegregates with CAD/MI in one family, and it suppresses transcription activation activity of MEF2A by a dominant-negative mechanism."
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