Down Syndrome

Gene expression in trisomy 21 T cells characterized

Published in Genomics and Genetics Weekly, March 18th, 2005

Gene expression in T cells from Down syndrome (DS) patients has been characterized.

DS "is caused by the presence of three copies of the whole human chromosome 21 (HC21) or of an HC21 restricted region; the phenotype is likely to have originated from the altered expression of genes in HC21," scientists in Italy explained.

In their study, S. Giannone and coauthors at the University of Bolgna used "the cDNA microarray method" to examine "gene expression in human T lymphocytes with trisomy 21 in comparison to normal cells."

"Two patients with DS were investigated, along with two normal subjects as a control, all being tested in...

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Source: Genomics and Genetics Weekly (2005-03-18)

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