Genomics and Genetics Weekly

HIV/AIDS Epidemic - Assay screens HIV-1 in epidemics characterized by mono/dual clade predominance

HIV/AIDS Pathogenesis - APOBEC3G antiviral function can dissociate from cytidine deaminase activity

HIV/AIDS Pathogenesis - HIV-1 catalytic core domain residues important for HIV-1 replication/integration

HIV/AIDS Pathogenesis - HIV-1 clade promoters strongly influence replication spatial/temporal dynamics

HIV/AIDS Pathogenesis - HIV-1-specific CD4+ cell turnover and activation increase upon viral rebound

HIV/AIDS Pathogenesis - POSH is essential for HIV-1 production

HIV/AIDS Research - "Preloaded" natural killer cells efficiently lyse HIV-infected target cells

HIV/AIDS Therapy - NNRTIs and RNase H inhibitors given in same HAART regimen may be beneficial

HIV/AIDS Therapy - Older antiretroviral strategies show renewed interest

HIV/AIDS Vaccine - Data on DNA-binding protein to correct human genes published online in 'Nature'

HIV/AIDS Vaccine - Segments of consecutive AA residues of HIV gp120 proposed as vaccine candidates

HIV/AIDS-Associated Emphysema - AIDS-associated emphysema due in part to HIV-1 infection of alveolar macrophages

HIV/AIDS-Related Hodgkin Lymphoma - LMP-1 deletion mutants highly associated with HIV-related Hodgkin's lymphoma

Head & Neck Cancer - Overexpression of p63 associated with poor prognosis in head and neck cancers

Hearing Disorders - Aminoglycoside controls hearing loss in those with A1555G mutations

Heat Shock Proteins - Heat shock studied, induction of histone phosphorylation revealed

Helicobacter Pylori -  H. pylori infection correlates with DNA damage in gastric mucosa cells

Hematology - Major functional genes become deregulated in acute myeloid leukemia subtypes

Hepatitis B Therapy - Long-term lamivudine improves outcomes for chronic hepatitis B patients

Hirschsprung Disease - Gene regions beyond protein instructions important in disease

Histone - Phe/Tyr switch analyzed, effect on histone lysine methyltransferases defined

Human Herpesvirus 6 - HHV-6B genes expressed during persistent infection identified

Human Papillomavirus-Associated Cancer - HPV strongly associated with several cancers independent of HIV infection

Hypertension - Rare promoter and coding region variants sway angiotensinogen levels

Hypertension - Studies advance knowledge in hypertension research

Immunology - Novel in vivo model facilitates study of alveolar macrophage gene function

Immunoreceptors - Immunoreceptor-ligand links studied, nature of associations clarified

Immunotherapy - Pre-emptive immunotherapy prevents relapse in children with MDS after ASCT

Inflammatory Diseases - Common factor is behind myocardial infarction, rheumatism and MS

Influenza Virus - Avian influenza strain causes lethal systemic infections in ferrets

Kidney Cancer - von Hippel-Lindau (VHL) tumor suppressor protein sensitized cancer to bortezomib

Leukemia - AS132 targeted specific proteins for destruction by the proteasome in leukemia

Leukemia - Distinct gene expression patterns linked to FLT3- and NRAS-activating mutations

Leukemia - Eight twenty-one homologues expressed during hematopoietic differentiation

Leukemia - SUMO-1 binding required for modification and colocalization with leukemia

Liver Cancer - HDPR1 downregulated in hepatocellular carcinoma

Liver Cancer - Molecular signatures characterize hepatocellular carcinoma

Liver Damage - Contrasting effects of telomere shortening explored

Liver Regeneration - Follistatin encourages retroviral-mediated gene transfer in liver cells

Lung Cancer - Glucocorticoids induce 15-PGDH in lung adenocarcinoma cells

Lung Injury Biomarker - Elevated sTNF receptors associated with morbidity/mortality in acute lung injury

Major Depressive Disorder - Underlying molecular mechanisms elucidated

Malaria - Mutations in pfmdr1 incur fitness cost in Plasmodium falciparum

Matrix Metalloproteinase - Ligament fibroblasts and alveolar bone cells studied, mRNA expression revealed

Melanoma - Eugenol caused melanoma growth suppression through inhibition of E2F1

Melanoma Vaccines - Studies advance knowledge in melanoma vaccines research

Meningitis - NucliSens EasyQ Enterovirus assay rapid and accurate

Mental Health - The features of schizotypy and personality share common genetic elements

Mergers & Acquisitions - Life sciences and high technology company completes acquisition of Proligo Group

Mitochondria - Correction of defects in patient-derived mutant mitochondria by tRNA* studied

Natural Killer Cells - Natural killer T cell development studied, nature of regulation clarified

Neurodegeneration - Oxidative stress upreglates genes associated with Alzheimer disease

Neurology - Expanded polyglutamine peptides studied, protein effects clarified

Neurology - Neuronal Ca²⁺ channel studied, role of phosphatase channel defined

Neurology - Neuronal dysfunction modeled, role of ubiquitin and nuclear inclusions revealed

Neurology - Prader-Willi syndrome protein necdin studied, role in axonal outgrowth defined

Neuroscience - Genetic interactions may establish susceptibility to anorexia nervosa

Neuroscience - Genetically modified fibroblasts treat Parkinson disease models

Neuroscience - Prostate innervation does not increase in postnatal rodents

Neuroscience - R208H mutations influence vulnerability to Creutzfeldt-Jakob disease

Obesity Genomics and Genetics - Human resistin gene polymorphism associated with visceral obesity

Obesity Pathogenesis - Findings describe new data in obesity pathogenesis research

Obstetrics - Pregnancy complications related to low levels of anti-clotting proteins

Oncogenesis - Unchecked DNA replication drives earliest steps toward cancer

Oncology - Alterations of pre-mRNA splicing in cancer analyzed

Oncology - Researchers provide details of new studies and findings in the area of oncology

Oncology - The genetics of bladder tumor progression in humans and mice are not the same.

Ophthalmology - Therapeutic target identified for modifying proteolytic environment

Osteocarcoma - PAF receptor antagonist potent/cytotoxic Ca2+ mobilizer in osteosarcoma cells

Osteopetrosis - High peripheral blood SCs enable autologous backup before SCT for osteopetrosis

Ovarian Cancer - Genetic changes in primary and secondary tumor sites compared

Ovarian Cancer - Progesterone-regulated tumor suppressor genes identified

Ovarian Cancer - Shape-altering genes explain development of different forms of disease

Parkinson Disease - Low neurotrophic factor levels lead to the loss of dopaminergic neurons

Parkinson Disease - Parkin examined, role in ubiquitination of synphilin-1 revealed

Personnel - Personalized medicine company adds two to scientific advisory board

Physiology - Basal disc cell differentiation studied, protein requirement and role defined

Physiology - Decapping reaction of mRNA studied, requirement for Dcp1 observed

Prenatal Diagnostics - Licensing agreement expands hCGa-based prenatal risk assessment

Product Licensing - Genomics company obtains exclusive license to develop new anemia drug

Prostate Cancer - Inhibition of IkappaB kinase activity promoted apoptosis in prostate cancer

Prostate Cancer - Phase I/II clinical trial begins in patients with recurrent prostate cancer

Prostate Cancer - Radiotherapy and sKDR gene delivery demolish malignant prostate tumors

Protein Expression -  Cryptococcus neoformans protein expression studied, genes implicated

Protein Signaling - Candidate EGFR gene targets identified in Drosophila

Proteomics - Endostatin works with membranes bearing phosphatidylserine to cause cell death

Proteomics - Exercise changes renal atrial natriuretic peptide receptor gene expression

Proteomics - Novel chip assay facilitates assessment of DNA-binding specificity

Proteomics - Researchers detail new studies and findings in the area of proteomics

Pulmonary Medicine - Repair-related gene expression is time-dependent following diaphragm injury

Pulmonary Medicine - Researchers describe findings in pulmonary medicine studies

Pulmonary Medicine - Shortened viral expression cassettes transfer genes to lung epithelia

RNA Research - Genome-wide RNAi screen of C. elegans published

Receptor-Mediated Signaling - G protein-coupled receptor studied, agonists and antagonists localized

Reproductive Medicine - LH-regulated genes identified in the primate corpus luteum

Reproductive Medicine - Novel alternative splice variant of BRDT gene cloned

Reproductive Toxicology - Vinclozolin- and procymidone-induced genes identified in rat ventral prostate

Restless Legs Syndrome - Major cause of insomnia has complex genetic involvement

Rheumatoid Arthritis - LymphoStat-B efficacious in patients with rheumatoid arthritis

Rheumatology - Non-transforming herpesvirus saimiri vectors regulate inflammatory cytokines

Roberts Syndrome - Fifteen-year hunt uncovers gene behind "pseudothalidomide" syndrome

SARS Coronavirus - Reports describe recent advances in SARS coronavirus research

Sexual and Reproductive Medicine - Altered ubiquitin-specific protease 26 gene may affect male fertility

Simian T-Cell Lymphotropic Virus Type 1 - Africa is origin of Tulane primate center STLV-1 sooty mangabey strain

Sjogren Syndrome - 5-Aza-CdR treatment induces aquaporin-5 expression in ductal cells

Skin Cancer - 1,25-Dihydroxyvitamin D-3 and analogues protect against UVB-induced DNA damage

Smooth Muscle - Fibulin-5 deficiency analyzed, role in smooth muscle function revealed

Stem Cell Research - A new embryonic stem cell line encodes a key cystic fibrosis mutation

Stem Cell Research - Hes1 has inhibitory role in Paneth cell differentiation in small intestine

Stem Cell Research - LIF induces kidney stem-like cell multilineage differentiation via cadherin 16

Stem Cell Research - Prolonged-survival neonatal PMNs have enhanced inflammatory/cytotoxic response

Stem Cell Research - Research needed to determine efficient delivery of SCs to appropriate sites

Stem Cell Research - SVP modifies self-renewal SC program to allow chronological change of cell fates

Stem Cell Research - Sonic hedgehog controls stem cell behavior in postnatal and adult brain

Stem Cell Research - alpha1LG4-5 provides vital signals for SC conversion to polarized epithelium

Stem Cell Research - c-Myb and p300 regulate stem cell proliferation and hematopoiesis

Stem Cell Transplantation - ABO incompatibility does not affect clinical outcome after APBSCT

Stem Cell Transplantation - Circulating DC subsets post-ASCT correlate with acute GVHD severity in children

Stem Cell Transplantation - PBSC graft composition affects outcomes after nonmyeloablative conditioning

Stem Cell Transplantation - Relaxation breathing does not improve leukocyte numbers in AHSCT

Stem-Cell Transplantation - Recent findings illuminate research in stem-cell transplantation

Suicidal Behavior Gene - Serotonin synthesis genes involved in predisposition to suicidal behavior

Testicular Cancer - Transcriptional repression domain in N-terminal region of p53 identified

Tissue Engineering - Researchers describe findings in tissue engineering studies

Toxicity - Podocyte heat shock proteins examined, influence of toxic metals revealed

Toxicology - Sibling profiles uncover a range of valproate-related developmental effects

Transplant Medicine - Noninvasive test to determines risk of rejection in heart transplant patients

Tuberculosis Vaccine - Control of human host immunity to mycobacteria reviewed

Type 2 Diabetes - Diachrome initiative for Native Americans living with type 2 diabetes announced

Umbilical Cord Blood - CB chromosomal aberrations associated with prenatal exposure to carcinogenic PAH

Vascular Graft - Procedure developed to extract RNA from cells seeded onto cylindrical conduits

Vector Development - Coated polymeric double-layered micelles transfect cells with low toxicity

Vector Development - Monoclonal antibody-PEI constructs conduct cell-specific nonviral gene delivery

Vibrio Parahaemolyticus - Vibrio multidrug antiporter studied, essential amino acids identified

Virology - Hepatitis C virus NS5B mutations affect viral load and interferon response

Virology - Hepatitis C virus isolates exhibit NS3 protease heterogeneity

Virology - High-powered living DNA cannon drives viruses

Virology - Recent findings illuminate research in virology