Atherosclerosis

ACAT2 is a therapeutic target for CHD associated with hypercholesterolemia

Published in Genomics and Genetics Weekly, July 29th, 2005

The ACAT2 enzyme is a therapeutic target for coronary heart disease associated with hypercholesterolemia, say Wake Forest University researchers.

"The inhibition of intracellular cholesterol esterification as a means to prevent atherosclerosis has been considered to have potential for many years. Two different ACAT enzymes were discovered about 7 years ago, and it has become clear that the two enzymes provide separate physiologic functions," wrote L.L. Rudel and colleagues.

They noted that "much has been learned from mice with gene deletions for either ACAT1 or ACAT2. Deletion of ACAT2 has consistently been atheroprotective whereas deletion of ACAT1...

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Source: Genomics and Genetics Weekly (2005-07-29)

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