Published in Genomics and Genetics Weekly, July 29th, 2005
Study 1: Mutant BRAF boosts melanoma cell dedifferentiation.
"Activating BRAF mutations and loss of wild-type INK4A expression both occur at high frequencies in melanomas. Here, we present evidence that BRAF and INK4A have different effects on melanogenesis, a marker of melanocytic differentiation," scientists in the United States report.
"Human melanoma cell line 624Mel harbors mutations in both BRAF and INK4A. The in vitro and in vivo growth of these cells was inhibited by either reduced expression of mutant BRAF using stable retroviral RNA interference...
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