Disease Associations

Parkinson disease phenotype examined, protective role of enzymes revealed

Published in Genomics and Genetics Weekly, July 29th, 2005

According to a recent study from the United States, overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat plus maneb-induced Parkinson disease phenotype.

"Oxidative stress has been implicated in the pathogenesis of Parkinson disease based on its role in the cascade of biochemical changes that lead to dopaminergic neuronal death. This study analyzed the role of oxidative stress as a mechanism of the dopaminergic neurotoxicity produced by the combined paraquat and maneb model of the Parkinson disease phenotype," wrote M. Thiruchelvam and colleagues, University of Medicine & Dentistry New Jersey.

"Transgenic mice...

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Source: Genomics and Genetics Weekly (2005-07-29)

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