Gene Research
Gene studies reveal the complexity of mouse apolipoprotein B gene expression
Published in Genomics and Genetics Weekly, July 29th, 2005
"An elevated plasma level of apolipoprotein B (APOB)-containing lipoproteins is a risk factor for atherosclerotic cardiovascular disease. Subtle genetic abnormalities in gene expression including an increased expression of the Apob gene may play an important role in determining overall risk," scientists writing in the journal Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids report.
"In an attempt to increase mouse Apob expression, we used gene targeting and duplicated approximately 65 kb of genomic DNA containing the Apob locus in its natural...
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