Genomics and Genetics Weekly
Susan Hasty, Publisher
Table of Contents . . . December 30th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Genomics and Genetics Weekly | Other Publications
Antisense Technology - Promoter hypomethylation marks the progression of chronic myeloid leukemia
DNA Research - Arizona researchers report a new technique for detecting DNA mutations
HIV/AIDS Therapy - RNA interference directed to CDK2 inhibits HIV-1 transcription
Hypoxia - Tumor hypoxia alters macrophage migration and gene expression
Nephrology - A new study finds an unexpected possible link between a gene in the liver and iron overload
Actin - Collapsin response mediator protein-4 regulates F-actin bundling
Addiction Medicine - Prodynorphin gene promoter polymorphism is linked to cocaine dependence
Alzheimer Disease - CYP46 T/C polymorphism is not linked to Alzheimer dementia
Alzheimer Disease - Microglial cell uptake of amyloid beta is promoted by protein up-regulation
Antioxidants - Catabolism of mitochondrial O2 *-/H2 O2 is essential for normal biological processes
Antisense Technology - Mitogen-activated protein kinases function in phospholipase D activity and oxidant production
Genetics & Genomics - Studies add new findings to genetics & genomics body of knowledge
Aphasia - Study links progressive aphasia to prion gene variants
Apoptosis - Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis
Apoptosis - Luteolin induces apoptosis in human malignant tumor cells
Apoptosis - Reports add new data to apoptosis research
Apoptosis - Zerumbone demonstrated anticancer potential
Apoptosis - siRNA depletion of 7SK snRNA induces apoptosis
Arthritis - Blockade of LT pathway appears to exacerbate autoimmune arthritis by skewing the Th1/Th2 balance
Arthritis - MMPs and cathepsin S pathways may be anti-inflammatory targets in arthritis
Attention Deficit Hyperactivity Disorder - Dopamine transporter (DAT1) gene is not associated with ADHD
Attention Deficit Hyperactivity Disorder - Genes regulating release of neurotransmitters studied in attention deficit hyperactivity disorder
Attention Deficit Hyperactivity Disorder - Sequence variation identified in the dopamine transporter gene
Behcet Disease - Interleukin-18 gene polymorphisms detected in Behcet disease
Biotechnology - Cell Sciences to distribute arrays including CombiMatrix's new influenza array
Bipolar Disorder - Evidence of genetic overlap of schizophrenia and bipolar disorder
Bipolar Disorder - Val66Met polymorphism in the BDNF gene is associated with bipolar disorder
Breast Cancer - CD44s used to differentiate between benign and malignant papillary lesions of the breast
Breast Cancer - Metallography assay for detection of HER2 gene status in breast cancer is developed
Breast Cancer - Metalloproteinase inhibition stimulates gene expression in breast cancer cells
Breast Cancer - Mice lacking cyclooxygenase-2 capacity have reduced mammary tumorigenesis and angiogenesis
Breast Cancer - Microarray CGH reveals genetic regulators of tumorigenic RTK signaling
Breast Cancer - Recent findings illuminate research in breast cancer
Burkholderia Cepacia - Epidemic Burkholderia cepacia complex clone infecting cystic fibrosis patients in Italy
Burkitt Lymphoma - T-cell leukemia-1 oncoprotein is expressed in pediatric Burkitt lymphoma
Business & Finance - Gene-focused biotechnology company secures financing from Greenwich Biotech Ventures
Cancer Gene Therapy - A maternal embryonic kinase is a promising target for multiple cancers
Cancer Gene Therapy - Recombinant vaccinia vSP could be a useful vector for tumor-directed gene therapy
Cancer Gene Therapy - Synthetic microRNA precursors can be used to probe tumor gene expression
Cancer Research - PTP1B is linked to latency and tumor type in p53-deficient mouse model
Cancer Therapy - Dosage guidelines determined for oral fixed-dose temozolomide
Cancer Therapy - Inerleukin-12 plus interferon reported to be safe as an experimental therapy for some cancers
Cancer Therapy - Myxoma virus has significant antitumor activity against human gliomas
Cancer Therapy - New tool for genetic data analysis may improve cancer treatment
Cancer Therapy - Research center and biosimulation company partner to improve services for cancer patients
Cardiology - 5-base pair deletion in CnB promoter region is linked to LV hypertrophy
Cardiology - Gene therapy improves cell-based approaches to cardiac neovascularization
Cardiology - Id1 gene transfer elicits therapeutic angiogenesis in ischemic lesions
Cardiology - Researchers detail new studies and findings in the area of cardiology
Cell Death - Nuclear factor-kappa proteins have opposing modulatory effects in cell death
Cell Differentiation - MEK5-ERK5 pathway is required for embryonic neural differentiation
Cell Research - Oligodendrocyte death is mediated by apoptosis-inducing factor
Cell Research - Sequential activation mediates apoptosis in gastric epithelial cells
Cervical Cancer - Reports advance knowledge in cervical cancer research
Chronic Hepatitis C Infections - Chronic hepatitis C virus infection produces milder damage in children than in adults
Chronic Hepatitis Infections - Paraoxonase-1 polymorphisms are associated with chronic HCV infection
Collaborations - Deal signed with RheoGene to commercialize research products using gene regulation technology
Collaborations - Genomics institute to partner with Morehouse School of Medicine on translational research
Collaborations - Institut Pasteur, drug maker to develop AIDS vaccine
Colon Cancer - Interleukin-6 advances tumor progression of human colon carcinoma cells
Colon Cancer Therapy - Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer
DNA Damage - Disruption of B-myb reveals novel B-Myb function in response to DNA damage
DNA Research - A chromatin-remodeling factor activates the colony stimulating factor 1 promoter
DNA Research - An antisense RNA plays a central role in the replication control of a repC plasmid
DNA Research - Chromatin organization modulates differential transcription of tRNA genes
DNA Research - DNA repair gene polymorphisms influence the yield of chromosomal aberrations
DNA Research - FCFM suitable for imaging single-cell apoptotic DNA fragmentation
DNA Research - GNAS mutations can be detected in peripheral blood cells
DNA Research - GW182 and a decapping complex crucial in miRNA-mediated gene silencing
DNA Research - Increased negative superhelical density enhances genetic instability of triplet repeat sequences
Developmental Biology - ATH5 basic domain mediates promoter activity during retina development
Developmental Biology - Krox20 has a role in neural tube patterning and respiratory control
Developmental Biology - Sequential deposition of binding proteins occurs in developing lung fibroblasts
Developmental Biology - Tissue-specific TAFs counteract polycomb to turn on terminal differentiation
Diabetes Epidemiology - CLPS Arg109Cys polymorphism variant may contribute to increased diabetes susceptibility
Diabetes Pathogenesis - Gene variant near SRD5A1 may affect 5-alpha-reductase type 1 activity and androgen levels
Diabetes Pathogenesis - p85 alpha negatively regulates muscle insulin signaling and induces GH insulin resistance
Diagnostics - Biological microbeads enable accurate and versatile flow cytometry testing
Diagnostics - Clinical application of DxS Scorpions technology licensed for in vitro diagnostics use
Diagnostics - Company focused on nucleic acids introduces versaGene DNA cell purification kit
Diagnostics - Real-time PCR improves diagnostic yield, but raises treatment costs
Diet & Nutrition - Combination of nutrigenomics and nutrigenetics will progress nutrition research
Diet & Nutrition - Consumption of cruciferous vegetables could prevent lung cancer
Diet & Nutrition - Ketogenic diet effective for seizure control in children
Diet & Nutrition - Microarray technology is expanding nutrition and food research
Diphtheria - Deletion of chrA/S C. diphtheriae genes causes heme sensitivity
Disease Associations - Approximately 5% of patients with influenza-like illness are human metapneumovirus-positive
Disease Associations - CFTR gene mutations are detected in infertile males
Disease Associations - KSHV LANA induces a strong bend on binding to terminal repeat DNA
Down Syndrome - Down syndrome screening proven more effective in first trimester
Drug Delivery - Insulin particles formed in supersaturated solutions of poly(Ethylene glycol) are proposed
Drug Development - ERK protein activation assists in adipocyte maturation and regulation of lipid blood level
Drug Development - Gene screening in yeast selects angiogenesis inhibitor
Drug Development - Gene-focused company expands alliance with Genentech to develop biotherapeutic drugs
Drug Development - Pharmacogenetics and genomics are leading the way into personalized medicine
Drug Resistance - Cyclooxygenase-1 haplotype modulates platelet response to aspirin
Drug Resistance - Gefitinib treats bronchioloalveolar carcinoma
Embryonic Development - Conserved regions in Forkhead Box f1 gene locus are essential for embryogenesis
Finance - Genetics testing company reports closure of $9 million debt financing note
Finance - Microarray products developer raises $8.2 million in private venture financing
Fragile X Syndrome - Mutated fragile X gene alters expression in cerebella immortal neuronal cell
Gastroenterology - Hepatocyte growth factor promotes mucosal repair in inflammatory bowel disease
Gastrointestinal Stromal Tumors - Surgery and molecular therapy used to treat gastrointestinal stromal tumors
Gene Research - Differential gene copy number detected using denaturing high performance liquid chromatography
Gene Research - Drosophila nucleosome remodeling factor is required for ecdysteroid signaling and metamorphosis
Gene Research - Genetic predisposition to cancer reviewed
Gene Research - Human homologue sensitizes Rap1 activation by epidermal growth factor
Gene Research - Mutations in dynein genes lead to axonemal hypersensitivity to Ca2+
Gene Research - Non-cell autonomous RNA silencing may exist in higher vertebrates
Gene Research - Urinary podocyte gene expression may be marker of acquired proteinuric diseases
Gene Research - Use of bioinformatics and genome analysis aids in discovery of new cancer therapeutics
Gene Research - sPLAA2 -IID polymorphism is linked to weight loss in chronic obstructive pulmonary disease
Gene Therapy - Endoribonuclease-prepared short interfering RNAs can silence mammalian genes
Gene Therapy - Hepatocellular carcinoma xenografts are eradicated by inducible gene therapy
Genetic Testing - CDC establishes program to develop quality control materials for genetic testing
Genetics & Genomics - A mutation accumulation assay reveals rapid evolution of gene expression
Genetics & Genomics - Collapse of p53 into clumps might be linked to cancer
Genetics & Genomics - Completed dog genome sequence shows new promise for canine and human health
Genetics & Genomics - Gene expression is altered after Wnt-mediated induction of avian neural crest
Genetics & Genomics - Gene expression profiling identifies downstream targets in glomeruli
Genetics & Genomics - Gene expression varies in the Bdellovibrio predatory life cycle
Genetics & Genomics - Human gene for FK506-binding protein 12.6 characterized and mapped
Genetics & Genomics - Leptin plays a role in the early immune response to pulmonary tuberculosis
Genetics & Genomics - MTB PE_PGRS33 gene polymorphisms are shifting along evolutionary lineages
Genetics & Genomics - Microarray-based system devised for multiplex amplifiable probe hybridization
Genetics & Genomics - New method integrates genotypic and expression data to identify obesity and bone trait gene
Genetics & Genomics - Paralogous pontin and reptin gene expression is simultaneous during development
Genetics & Genomics - Research add new data to genetics & genomics body of knowledge
Genetics & Genomics - Spermatogonial SCs retain euploid karyotype and androgenetic imprint during long-term culture
Genetics & Genomics - TCBA1 gene may be mutated in genetic diseases with a neurological phenotype
Genetics & Genomics - Up-down properties of microarray expression series useful for gene identification
Genomics - Clinical assays firm announces genotyping assay as enhancement to pharmacogenetics testing
Genomics - Researchers discover means to increase expression of hypoxia-sensitive genes
Geriatrics - Klotho-induced inhibition of insulin/IGF-1 signaling is linked to anti-aging
Germ Cell Cancer - KIT pathway is constitutively activated in testicular germ cell tumors
Gliomas - Role of chemotherapy in the treatment of low-grade glioma reviewed
HIV/AIDS Diagnostics - Bayer TruGene genotype assay detects and characterizes non-subtype-B HIV-1 strains
HIV/AIDS Diagnostics - HIV-1 subtypes CRF01_AE and B' can be genotyped by heteroduplex mobility assay and peptide ELISA
HIV/AIDS Evolution - Cellular immune selective pressures drive individual and global HIV-1 evolution
HIV/AIDS Legal Issues - Molecular testing determines multiple HIV-1 transmissions in a criminal case
HIV/AIDS Pathogenesis - Mitochondrial complex I activity is impaired during HIV-1-induced T-cell apoptosis
Haemophilus Influenzae - H. influenzae capsule deficient serotype can establish an invasive infection
Health Perception - Interview study finds personal experience and emotional impact influence risk perceptions
Helicobacter Pylori - Helicobacter pylori infection alters gastric epithelial cell gene expression
Helicobacter Pylori - Cytotoxin genotype changes during infection with H. pylori infection
Hepatitis B Therapy - Genomic analysis conducted of anti-hepatitis B virus activity
Hepatitis B Virus - Hepatitis B virus genotypes are not associated with extrahepatic manifestations
Hepatitis B Virus - Hepatitis B virus mutation is linked with excessive nucleocapsid protein expression
Hepatitis B Virus Transmission - HBV transmission is clarified by genotyping and phylogenetic analysis
Hepatitis C Virus - HCV RNA-dependent RNA polymerase residues are important in RNA synthesis
Hepatitis C Virus - HCV core protein inhibits electron transport and increases reactive oxygen species production
Hepatitis C Virus - Hepatitis C virus core protein inhibits suppressor of cytokine signaling-1 gene expression
Hepatitis C Virus - Stable hepatitis C virus culture system robustly produces infectious virus
Hepatocellular Carcinoma - Frizzled receptor has an oncogenic role in hepatocellular carcinoma
Hereditary Spastic Paraplegia - Hereditary spastic paraplegia disease-related phenotypes are ameliorated by vinblastine
Herpesvirus - Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression
Hormones - Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
Hormones - Specific gene polymorphisms are not associated with bone size and height
Human Papillomavirus - DEK proto-oncogene is a senescence inhibitor and an upregulated target of human papillomavirus E7
Immunotherapy - Naive T cells are primed by inflammatory cytokines
Infectious Diseases - FimH gene of Salmonella enterica serovar Enteritidis analyzed
Infectious Diseases - The neuraminidase gene is present in non-toxigenic Vibrio cholerae
Inflammatory Bowel Disease - Inflammatory bowel disease can be treated with NF-kappa B decoy oligonucleotides
Inflammatory Bowel Disease - Intestinal epithelial eotaxin gene expression is up-regulated in inflammatory bowel disease
Joint Replacement - Cobalt-chromium alloys can cause DNA damage after prosthesis wear
Keratoconus - Incidence and severity of keratoconus abnormally high in Saudi Asir province
Lactation - Role of compensatory mammary growth studied in epigenetic control of gene expression
Leukemia - Reports advance knowledge in leukemia research
Lung Cancer - Aberrant methylation of H-cadherin promoter associated with tumor progression in lung carcinoma
Lymphoma - Curcumin induced apoptosis in primary effusion lymphoma
Malaria - Host microsatellite alleles of TH01 and D5S818 are indicator of malaria susceptibility
Malaria - Researchers' work adds to malaria body of knowledge
Measles Vaccine - Recombination occurs among early-vaccination-era measles virus strains
Medical Devices - New TaqMan Low Density Array Gene Signature panels launched for common drug targets
Memory - Vestibular loss causes hippocampal atrophy and impaired spatial memory
Metabolic Syndrome - Recent findings in metabolic syndrome described
Molecular Biology - New muscle-building agent reported effective in mouse model
Mucosal Injury Prevention - Short-chain fatty acid induces intestinal mucosal injury
Mycobacterium Tuberculosis - Induction of macrophage-derived SLPI by MTB depends on TLR2 but not MyD88
Myeloma - Clinical factors predictive of outcome with bortezomib studied in patients with multiple myeloma
Myoblast Cells - Myoblast proliferation and differentiation is regulated by a pregnancy-associated plasma protein
Nanobiology - Vitrobot, a new cryo sample prep tool for organic samples, introduced
Neurology - Research in neurology provides new insights
Neuroscience - C. elegans Fox-1 protein homologues regulate neuronal splicing in mammals
Neuroscience - H101Q mutation causes protein kinase C gamma loss in neurodegeneration
Neuroscience - Nerve growth factor effects in dorsal root ganglia neurons can be modulated
Neuroscience - Reduced Aph-1b expression alters gamma-secretase activity
Obesity Epidemiology - Genetics behind human obesity and DNA progress is addressed
Oncogenesis - Subtle EGF-receptor point mutations create a potent oncoprotein
Oncology - Bone morphogenetic protein 2 may stimulate tumor angiogenesis
Oncology - Macrophages may be needed for IL-1 beta-induced tumor growth and angiogenesis
Oncology - Recent studies add new data to oncology research
Oncology - Study finds E3 ubiquitin ligase is an attractive oncology target
Ophthalmology - Thrombophilic gene polymorphisms do not notably raise branch retinal vein occlusion risk
Ovarian Cancer - Immunophenotype of primary ovarian cancer and metastatic breast cancer to the ovary compared
Pancreatic Hyperenzymemia - CFTR gene mutation is not crucial in idiopathic pancreatic hyperenzymemia
Patents - Georgia company applies for U.S., foreign patent protection of prostate disease biomarkers
Personnel - Daniel Boulais, Diane Lanctot named to board of genomics-based biotech company
Personnel - Dr. Jonathan W. Said joins CombiMatrix Molecular Diagnostics' scientific advisory board
Personnel - Functional genomics firm appoints Daniel H. Farkas as VP of clinical diagnostics
Personnel - Genetic analysis products company announces three new hires for service business
Pituitary Cancer - Features of somatotroph and lactotroph adenomas detailed
Pneumonia Vaccine - Age-related changes occur in light-chain gene usage in response to pneumococcal polysaccharides
Professional Education - Nonprofit forms Center of Excellence in Computational Biology
Prostate Cancer - Aberrant expression of Delta Np73 detected in benign and malignant tumors of the prostate
Prostate Cancer - Androgen receptor-mediated cell growth is modulated in prostate cancer
Prostate Cancer - Metabolomics company selected for membership in U.S. NCI research group
Prostate Cancer - Protein up-regulation leads to xenograft growth inhibition and apoptosis
Prostate Cancer Therapy - Apoptosis in human prostate cancer cells is induced by kinase activation
Protein Production - Method for automated expression and solubility screening of His-tagged proteins is developed
Proteomics - Altered beta 1 integrin sialylation activates myeloid fibronectin receptors
Proteomics - Interleukin-21 receptor gene induction is mediated by T-cell receptor-induced Sp1 activity
Proteomics - Regulation of wild-type and Y1235D mutant Met kinase activation revealed
Proteomics - STAT3-inducible Bcl6 variant 2 promotes survival and proliferation of IL-6-dependent tumor cells
Prothrombin - Factor V and prothrombin nucleotide polymorphisms vary among Arabs
RNA Research - An artificial riboswitch controls pre-mRNA splicing
RNA Therapy - Small interfering RNA may be more therapeutically efficient than antisense oligonucleotide
Rheumatology - Data advance knowledge in rheumatology research
SARS Coronavirus - Findings describe new data in SARS coronavirus research
Salmonellosis - Salmonella stress management is related to behavior during intestinal colonization
Schizophrenia - Disruption of gene interaction linked to schizophrenia
Schizophrenia - Transmission disequilibrium suggests a role for the sulfotransferase-4Al gene in schizophrenia
Smooth Muscle - Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1
Spinocerebellar Ataxia - Haplotype diversity and somatic instability detected in spinocerebellar ataxia
Squamous Cell Carcinoma - The Akt-mTOR pathway is a target of rapamycin in squamous cell carcinomas
Stem Cell Research - Corneal stroma cells express stem cell markers and exhibit multipotent differentiation potential
Stem Cell Research - Research shows suitable method for derivation and long-term growth of ESCs
Stem Cell Transplantation - Almost half of HSCT patients with high-grade CMV antigenemia develop CMV disease
Stem Cell Transplantation - Chromosome 5 and/or 7 abnormalities in AML or MDS associated with high relapse rate following ASCT
Stem Cell Transplantation - Multiple myeloma patients do not benefit from autologous stem cell transplantation
Stem Cell Transplantation - Recombinant erythropoietin improves post-stem cell transplantation hemoglobin recovery
Stress Response - Menin is a regulator of the stress response in Drosophila melanogaster
Transplant Medicine - New findings in the area of transplant medicine detailed
Transplant Medicine - Vessel growth sustains fat graft survival mechanisms in study models
Tuberculosis - Mycobacterium caprae is a distinct phylogenetic lineage within the MTB complex
Type 1 Diabetes - Glu23Lys polymorphism in KCNJ11 is not a risk factor for impaired hypoglycemia awareness
Vascular Dementia - SREBF2 gene is a genetic risk factor for vascular dementia
Virology - An interferon-stimulated gene is an antiviral molecule in Sindbis virus infection
Virology - Lymphoblastoid cell lines require Epstein-Barr virus to produce vascular endothelial growth factor
Virology - Reports add new data to virology research
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