Genomics and Genetics Weekly

Atherosclerosis - Two proteins participate in the repression of paraoxonase-1 gene expression

Endocrinology - Insulin control of placental gene expression shifts from mother to fetus over pregnancy term

Genetics & Genomics - Galactosemia patients have decreased height and abnormal body composition

Parkinson Disease - UCLA scientists find male gene in brain area targeted by Parkinson disease

Transgenics - A virus-neutralizing antibody is not cytotoxic in vitro

Addiction Medicine - Cocaine reinforcement is attenuated by antisense-induced protein reduction

Adenomas - DNA methylation patterns of adenomas studied

Adenovirus - T-cell epitope repertoire is predicted from human and viral genomes

Allergy & Immunology - Ets1 participates in IL-5 transcription regulation in mouse lymphocytes

Allergy & Immunology - Innate immune response gene induction by hantavirus does not require viral replication

Allergy & Immunology - Pen ch 13 may contribute to asthma

Alzheimer Disease - Metallothionein-3 and neuronal nitric oxide synthase found reduced in Alzheimer disease

Angina - Update on GENASIS trial announced by Corautus Genetics

Angiogenesis - Angiogenesis is inhibited by thrombospondin targeting of type I collagen

Angiology - Chronic hypoxia modulates melatonin receptors in the rat carotid body

Angiology - Tumor angiogenesis flourishes in models with TIMP-3 gene deficiency

Apoptosis - Cyclin D1 overexpression induces apoptosis resistance linked to carcinoma BCL-2

Apoptosis - Imatinib reported to induce apoptosis

Apoptosis - Researchers describe findings in apoptosis studies

Apoptosis - Retinoblastoma plays a role in survival of Abl-dependent human tumor cells

Apoptosis - Studies advance knowledge in apoptosis research

Assisted Reproduction - Research add new data to assisted reproduction body of knowledge

Atherosclerosis - Researchers' findings advance atherosclerosis research

Autism - PediaMed completes clinical trial enrollment to study GI dysfunction in children with autism

Avian Influenza - CombiMatrix launches next generation of its Influenza A surveillance technology: 4X2K

Bipolar Disorder - Functional polymorphisms are associated with bipolar disorder

Breast Cancer - Breast cancer found associated with steroid receptor RNA activator protein expression

Breast Cancer - Breast cancer linked to expression of autocrine motility factor

Breast Cancer - HER-2/neu expression used to prognosticate primary breast cancer

Breast Cancer - Hirsutenone inhibits COX-2 and MMP-9 upregulation in mammary epithelial cells

Breast Cancer - Research add new data to breast cancer body of knowledge

Breast Cancer Vaccine - Breast cancer tumors frequently express cancer testis genes

Business & Finance - Fourth-quarter 2005 results reported by Cepheid; total revenues increase 16%

Business & Finance - Transgenomic receives letter of noncompliance from Nasdaq Stock Market

Business Update - Additional CRDA with the U.S. Air Force announced by CombiMatrix

Business Update - Genome analysis system developer Solexa transfers listing to Nasdaq National Market

Business Update - Licensing program in Europe expanded by Genetic Technologies

Cancer Gene Therapy - PEG10 is a c-MYC target gene in cancer cells

Cancer Gene Therapy - Peroxiredoxin I expression affects lung tumor growth and radiosensitivity

Cancer Gene Therapy - RNA interference induces cell cycle arrest and apoptosis in breast carcinoma cells

Cancer Therapy - Antisense therapy is well tolerated in patients with metastatic colorectal cancer

Cancer Therapy - Cisplatin functions as ARF mimic

Cancer Therapy - New findings in cancer therapy described

Cancer Therapy - Phenylcarbazoles display antitumor properties

Cancer Therapy - Studies advance knowledge in cancer therapy research

Cancer Therapy - Studies describe new findings in cancer therapy research

Cancer Therapy - Thymosin beta 4 determines fibroblast transformation and invasiveness

Cardiology - Ghrelin and synthetic affect cardiovascular GH secretagogues

Cardiology - Maintenance of normal myocyte growth may require E2F-6

Cardiovascular Disease - Dilated cardiomyopathy pathogenesis and role of beta₁ -adrenergic receptor is reviewed

Carotid Body Tumor - Current concepts for surgical management of carotid body tumor discussed

Celiac Disease - ACS5 may be a suitable marker for the detection of celiac disease

Cervical Cancer - Cervical cancer growth is inhibited by the angiogenesis modulator NOL7

Chondrogenesis - SCRG1 is induced by glucocorticoid and stimulates chondrogenesis in vitro

Collaborations - Research collaboration to develop micro-RNA related therapies for liver cancer announced

Colon Cancer - 9-aminocamptothecin-HPMA copolymer conjugates developed for colon cancer drug delivery

Colorectal Adenocarcinomas - Colorectal carcinoma tumor-associated stroma has a metabolic survival role

Colorectal Cancer - Colorectal cancer linked to aberrant promoter methylation of multiple genes

Colorectal Cancer - Expression of p53 mutations in colorectal cancer cell lines examined

Colorectal Cancer - Link between polymorphisms and environmental factors in colorectal cancer risk discussed

DNA Research - Cellular delivery of nucleic acid conjugates is mediated by cationic lipids

DNA Research - ReliaGene Technologies introduces Y-Screen for forensic analysis of male DNA

DNA Vaccine - Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine

Dengue Fever - Dengue antigen developed

Developmental Biology - FGF signaling establishes gut tube domains along the anterior-posterior axis

Developmental Biology - Nephric duct morphogenesis and guidance in the developing kidney requires Gata3

Diabetes Epidemiology - Metabolic traits likely due to genetic effects

Diabetes Pathogenesis - GNB3 825C >T polymorphism do not seem to be involved in metabolic syndrome

Diabetes Pathogenesis - Insulin gene VNTR, insulin immune response, and beta cell function are linked T1DM

Diabetes Pathogenesis - New research in the area of diabetes pathogenesis detailed

Diabetes Therapy - Ghrelin-induced IA-2 beta inhibits glucose-stimulated insulin secretion

Diabetes Therapy - Nuclear receptor activation improves hyperglycemia and hyperlipidemia in diabetic mice

Diabetes Therapy - Resistin exposure regulates skeletal muscle cell insulin signaling, glucose uptake, and metabolism

Diabetic Angiopathy - Diabetic angiopathy may be controlled by the transcription factor ATF3

Diabetic Nephropathy - Nephropathy in type 2 diabetes may be linked to p22phox C242T polymorphism

Diagnostics - CE IVD-marked products launched in Europe by Cepheid

Diagnostics - DNA-based assay for rapid prenatal detection of common chromosome abnormalities released

Diagnostics - Mixed Mycobacterium lentiflavum and M. avium infections detected by genotyping

Diagnostics - Recent findings in diagnostics described

Diagnostics - U.S. FDA 510(k) clearance for Nanopia wrCRP Assay received by Clinical Data

Diet & Nutrition - Dopaminergic activity influences reinforcing value of food

Drug Delivery - A biodegradable polymer functions as a carrier material

Drug Delivery - CoStar drug-eluting stent gets CE Mark

Drug Delivery - Miniaturized ChronoDose Prototype unveiled by ChronoTherapeutics

Drug Delivery - Polymer-coated targeted drug delivery systems stochastically modeled

Drug Development - Angiogenesis protein is counteracted by new aminonucleosides

Drug Development - Biotech company selects Isis to manufacture, supply antisense drug for eye diseases

Drug Development - Combination of porphyrins and DNA-alkylation agents described

Drug Development - Pharmacogenomics added to development of new marine-derived anticancer agents

Drug Development - Two novel, small-molecule inhibitors of DNA methylation discovered

Drug Discovery - Models for simulation of signaling network aid in silico evaluation of drug candidates

Drug Resistance - Reduced Neisseria gonorrhoeae ceftriaxone susceptibility is linked to multidrug-resistance

Endocrinology - Arg decarboxylase regulates agmatine in brain regions and neuronal cells

Endometrial Carcinoma - Endometrial carcinoma progression is associated with HOXA10 deregulation

Epidemiology - FUT2 nonsecretor genotype associated with resistance to norovirus outbreaks

Epilepsy - SCN1A-associated epilepsy is linked to a channel dysfunction

Facilities - Cambridge, Massachusetts new office site for Gene Network

Finance - Lexicon Genetics reports 23% annual revenue growth for 2005

Finance - Mesothelioma Applied Research Foundation awards nearly $1 million for research aimed at a cure

Finance - Nutrigenomics-focused biotechnology company completes $3 million series B financing

Foamy Virus Infection - Foamy virus RNA quantified in tissues of healthy and SIV-infected macaques

Gastrointestinal Stromal Tumors - Researchers describe findings in gastrointestinal stromal tumors studies

Gene Research - De novo CpG island methylation in human cancer cells discussed

Gene Therapy - Phenylketonuria gene expression profile is reversed by gene therapy

Genetics & Genomics -  Mycobacterium avium genes associated with biofilm formation

Genetics & Genomics - A novel mutation at the JK locus causes Jk(Null) phenotype

Genetics & Genomics - Atrial fibrillation may produce gene-expression changes related to arrhythmia

Genetics & Genomics - BioInformatics study shows New England Biolabs leads restriction enzyme market

Genetics & Genomics - Data advance knowledge in genetics & genomics research

Genetics & Genomics - Free online gene and protein synonyms database now available

Genetics & Genomics - Genes involved in cell growth and cell division identified

Genetics & Genomics - GenomeQuest adopted by Chiron, says Gene-IT

Genetics & Genomics - Multilocus gene polymorphisms and risk of myocardial infarction are evaluated

Genetics & Genomics - Post-transcriptional signals yield macrophage VEGF

Genetics & Genomics - Sigma announces new licensing agreement with Rubicon for whole genome amplification rights

Genetics & Genomics - UCP2 and UCP3 polymorphisms linked to reduction in diabetic neuropathy prevalence

Geriatrics - Interleukin promoter single nucleotide polymorphisms are associated with aging

Guillain-Barre Syndrome -  C. jejuni serotype HS:19 predicts Guillain-Barre syndrome development

HIV/AIDS Adverse Drug Reactions - Adverse events are most common reasons for generic HAART modification in Southern India

HIV/AIDS Diagnostics - Genotypic and phenotypic clinical cut-off levels determined for ritonavir-boosted saquinavir