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HIV/AIDS Pathogenesis

CTL targeting of HIV-1 is similar in identical twins 20 years after neonatal infection

Published in Genomics and Genetics Weekly, March 24th, 2006

Cytotoxic T lymphocyte targeting of HIV-1 is similar in identical twins 20 years after neonatal infection.

According to recent research from the United States, "Human immunodeficiency virus type 1 (HIV-1) evolves in vivo under selective pressure from CD8+ T-lymphocyte (CTL) responses, which are in turn determined by host and viral genetic factors, such as restricting major histocompatibility complex molecules and the available viral epitope sequences.

"However, CTL are derived stochastically through the random gene rearrangements to produce T-cell receptors (TCR), and the relative impact of genetic versus stochastic processes on CTL targeting of HIV...

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