Genetics & Genomics
Viral gene expression activation identified in polarized epithelial monolayers
Published in Genomics and Genetics Weekly, June 16th, 2006
"Epithelial polarity and tight junction formation limit the ability of adenovirus, retrovirus and adeno-associated virus (AAV) to deliver and express virally encoded genes. Using an extended half-life luciferase assay and high-throughput luminometry, we screened 23,000 compounds and natural product extracts as potentiators to overcome this barrier," wrote E.J. Sorscher and colleagues, University of Alabama.
"Seven strong activators were discovered (up to several hundred fold above control) and two of these...
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