Genomics & Genetics Weekly
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Apoptosis
Apoptosis in myelodysplastic syndromes clarified
July 14th, 2006
Research from the United States has reported that apoptosis in myelodysplastic syndromes (MDS) involves dysregulated human myeloid nuclear differentiation antigen (MNDA) expression. "Reduced levels of human MNDA gene transcripts have been detected in both familial and sporadic cases of MDS. Numerous reports implicate elevated apoptosis/programmed cell death and death ligands and their receptors in the pathogenesis of MDS," wrote R.C. Briggs and colleagues, Vanderbilt University. "MNDA and related proteins contain the pyrin domain that functions in signaling associated with programmed cell death and inflammation. We tested the hypothesis that MNDA is...
Source: Genomics & Genetics Weekly (2006-07-14)
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