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Atherosclerosis
Atherosclerosis is affected by decreased heat shock protein 27 HSP27
July 14th, 2006
According to recent research from France published in the journal Arteriosclerosis Thrombosis and Vascular Biology, atherosclerosis is affected by decreased heat shock protein 27 (HSP27). "Because culprit atherosclerotic plaques contain proteases, we hypothesized that the diminished HSP27 released by atherosclerotic plaques could be due to proteolysis. We assessed the role of HSP27 in human vascular smooth muscle cells (VSMCs) under proteolytic injury," wrote J.L. Martin-Ventura and colleagues, INSERM U698. "Active plasmin is present in culprit atherosclerotic plaques. Recombinant HSP27 was cleaved by plasmin and this effect was prevented by...
Source: Genomics & Genetics Weekly (2006-07-14)
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