Genomics & Genetics Weekly
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Bladder Cancer
Bladder cancer survival linked to cyclin D3 expression
July 14th, 2006
Progression-free survival of patients with primary Ta/T1 bladder cancer could be linked to cyclin D3 expression. "Cyclin D3 deregulation has recently been reported in bladder cancer but its prognostic significance remains uncertain. A cohort of 159 patients with stage Ta or T1 primary bladder tumours was investigated to determine the significance of cyclin D3 expression in association with other G1-S phase regulators of the cell cycle (p53, p21Waf1, p27kip1, cyclin D1), including tumor proliferation (ki67-MIB1); its association with conventional clinicopathological parameters; and the relationship between cyclin D3 and loss of heterozygosity (LOH) at the 9p21 (p161NK4a...
Source: Genomics & Genetics Weekly (2006-07-14)
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