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Breast Cancer
Breast cancer risk is increased in high-risk Jewish women with specific ATM gene mutations
July 14th, 2006
Breast cancer risk is increased in high-risk Jewish women with specific ATM gene mutations. "While genetic factors clearly play a role in conferring breast cancer risk, the contribution of ATM gene mutations to breast cancer is still unsettled," according to researchers in Israel. "To shed light on this issue, ATM haplotypes were constructed using eight SNPs spanning the ATM gene region (142 kb) in ethnically diverse non-Ashkenazi Jewish controls (n=118) and high-risk (n 142) women." M. Koren and colleagues from the Chaim Sheba Medical Center in Tel-Hashomer reported, "Of the 28 haplotypes noted, four were encountered in frequencies of 5% or more and...
Source: Genomics & Genetics Weekly (2006-07-14)
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