Genomics & Genetics Weekly
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Breast Cancer
Breast carcinogenesis linked to activating function of c-Src and Stat3 on HGF transcription
July 14th, 2006
Breast carcinogenesis was linked to a novel activating function of c-Src and Stat3 on hepatocyte growth factor (HGF) transcription. According to a study from Canada, "In the normal breast, HGF is primarily expressed by stromal cells, and stimulates in a paracrine manner epithelial cells expressing the HGF receptor (Met). In invasive human breast carcinomas, HGF and Met are frequently overexpressed, possibly establishing an autocrine HGF/Met loop that promotes tumor cell invasion. However, the mechanisms leading to autocrine HGF expression in carcinoma cells are not known." "We previously demonstrated a cooperative effect between c-Src and Stat3 in...
Source: Genomics & Genetics Weekly (2006-07-14)
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