Genomics & Genetics Weekly
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Breast Cancer
Breast tumor progression-specific genes identified
July 14th, 2006
A study from Germany has reported on the identification of progression-specific genes by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. "Becoming invasive is a crucial step in breast cancer oncogenesis. At this point, a lesion carries the potential for spreading and metastasis - a process, whose molecular characteristics still remain poorly understood. "In this article, we describe a matched-pair analysis of ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of nine breast ductal carcinomas to identify novel...
Source: Genomics & Genetics Weekly (2006-07-14)
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