Genomics & Genetics Weekly
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Embryonic Stem Cell Research
Lineage-specific genes are primed for expression in embryonic stem cells
July 14th, 2006
Lineage-specific genes are primed for expression in embryonic stem cells but are held in check by opposing chromatin modifications. "Epigenetic genome modifications are thought to be important for specifying the lineage and developmental stage of cells within a multicellular organism. "Here, we show that the epigenetic profile of pluripotent embryonic stem cells (ES) is distinct from that of embryonic carcinoma cells, haematopoietic stem cells (HSC) and their differentiated progeny," investigators in England report. According to V. Azuara and colleagues at the Imperial College School of Medicine in London, "Silent, lineage-specific genes...
Source: Genomics & Genetics Weekly (2006-07-14)
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