Genomics & Genetics Weekly
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Cancer Gene Therapy
Endostatin therapy reveals a U-shaped curve for antitumor activity
July 14th, 2006
A recent study from the United States has reported that endostatin therapy reveals a U-shaped curve for antitumor activity. "Developing continuous systemic delivery of endostatin has been a goal of many laboratories. We have employed a method of gene therapy utilizing different viral constructs. "Here, we report that a new serotype of adeno-associated viruses, which incorporates canine endostatin, provides dose-dependent transgene expression in the circulation after intramuscular injection in mice," wrote R.T.T. Sjin and colleagues, Harvard University. "Elevated levels of endostatin remained stable in the circulation for at least...
Source: Genomics & Genetics Weekly (2006-07-14)
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