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Cancer Gene Therapy
Selective adenovirus replication requires enhanced E1A expression in cancer cells
July 14th, 2006
According to recently published research from the United States, selective replication of E1B55K-deleted adenoviruses depends on enhanced E1A expression in cancer cells. "E1B55K-deleted dl1520 could selectively replicate in cancer cells and has been used in clinical trials as an antitumor agent. The mechanism of virus selective replication in cancer cells, including a possible role of p53, is unclear," wrote X. Zheng and colleagues, University of Louisville. "Studies with established cancer cell lines have demonstrated that some cancer cells are resistant to dl1520 replication, regardless of the p53 status. Hep3B cells supported the E1b-deleted...
Source: Genomics & Genetics Weekly (2006-07-14)
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