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Genomics & Genetics Weekly

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Cancer Gene Therapy



Squamous cell carcinoma adenoviral p53 gene therapy evaluated



July 14th, 2006

A study from Japan has reported on the evaluation of a squamous cell carcinoma adenoviral p53 gene therapy.

"We investigated the feasibility, safety, biological activity and therapeutic efficacy of adenovirus-mediated p53 gene transfer in patients with chemoradiation resistant advanced esophageal carcinoma," wrote H. Shimada and colleagues, Chiba University.

They explained, "Eligible patients were not surgical candidates and had measurable, advanced squamous cell carcinoma of the esophagus that was resistant to chemoradiation therapy. On a 28-day cycle, intratumoral injections of Ad5CMV-p53 (INGN 201; ADVEXIN) were administered on days 1 and 3 at...


Source: Genomics & Genetics Weekly (2006-07-14)

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