Genomics & Genetics Weekly
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Cancer Risk
Cancer risk in non-smokers linked to DNA repair polymorphisms
July 14th, 2006
Cancer risk in non-smokers could be linked to DNA repair polymorphisms, but requires further investigations. According to recent research published in the journal Carcinogenesis, "Environmental carcinogens contained in air pollution, such as polycyclic aromatic hydrocarbons, aromatic amines or N-nitroso compounds, predominantly form DNA adducts but can also generate interstrand cross-links and reactive oxygen species. If unrepaired, such lesions increase the risk of somatic mutations and cancer." "Our study investigated the relationships between 22 polymorphisms (and their haplotypes) in 16 DNA repair genes belonging to different repair...
Source: Genomics & Genetics Weekly (2006-07-14)
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