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Cancer Therapy
Angiogenesis and tumor progression can be inhibited by genetic cotransfection
July 14th, 2006
A study from South Korea has reported on the inhibition of angiogenesis and tumor progression by hydrodynamic cotransfection of angiostatin K1-3, endostatin, and saxatilin genes. "In vivo expression of angiostatin and endostatin, two different types of endothelial cell growth inhibitor, have been reported to inhibit vascularization in tumor tissues, resulting in tumor growth inhibition. Recently, in vivo expression of saxatilin, a novel disintegrin purified from snake (Gloydius saxatilis) venom, was able to strongly inhibit endothelial cell proliferation and smooth muscle cell migration, resulting in tumor growth inhibition," wrote K.S. Kim and colleagues, Yonsei...
Source: Genomics & Genetics Weekly (2006-07-14)
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