Genomics & Genetics Weekly
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Cancer Therapy
Myc-mediated tumorigenesis explored using reversible kinetic analysis
July 14th, 2006
According to recently published research from the United States, reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. "Deregulated expression of the Myc transcription factor is a frequent causal mutation in human cancer. Thousands of putative Myc target genes have been identified in in vitro studies, indicating that Myc exerts highly pleiotropic effects within cells and tissues," wrote E.R. Lawlor and colleagues, University of California, San Francisco. "However, the complexity and diversity of Myc gene targets has confounded attempts at identifying which of these genes are the critical targets...
Source: Genomics & Genetics Weekly (2006-07-14)
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