Genomics & Genetics Weekly
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Cardiovascular Research
Arterial calcification is actively regulated by bone-matrix associated proteins
July 14th, 2006
The occurrence of arterial calcification in C3H/He mice after freeze-thaw injury seems to be actively regulated by certain bone-matrix associated proteins. Researchers in Germany report, "Vascular calcification is highly correlated with atherosclerosis and cardiovascular disease and is a significant predictor of cardiovascular morbidity and mortality. Studies in mice indicate a genetic contribution to this dystrophic extra osseous calcification." "We sought to elaborate a method to induce dystrophic arterial calcification in mice and further examine the pathogenetical mechanisms involved in the phenotype," wrote L.C. Doehring and colleagues at...
Source: Genomics & Genetics Weekly (2006-07-14)
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