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Cell Biology
Caldesmon is an integral component of podosomes in smooth muscle cells
July 14th, 2006
According to recently published research from Canada, caldesmon is an integral component of podosomes in smooth muscle cells. "Podosomes are highly dynamic actin-based structures commonly found in motile and invasive cells such as macrophages, osteoclasts and vascular smooth muscle cells. Here, we have investigated the role of caldesmon, an actin-binding protein, in the formation of podosomes in aortic smooth muscle A7r5 cells induced by the phorbol ester PDBu," wrote R. Eves and colleagues, Queens University. "We found that endogenous low molecular weight caldesmon (1-caldesmon), which was normally localised to actin-stress fibres and membrane...
Source: Genomics & Genetics Weekly (2006-07-14)
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