Genomics & Genetics Weekly
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Cell Biology
Cortactin affects cell migration
July 14th, 2006
According to recent research published from the Netherlands, cortactin affects cell migration by regulating intercellular adhesion and cell spreading. "Cortactin is an F-actin binding protein that stabilizes F-actin networks and promotes actin polymerization by activating the Arp2/3 complex. Overexpression of cortactin, as observed in several human cancers, stimulates cell migration, invasion, and experimental metastasis; however, the underlying mechanism is not understood," wrote A.G.S.H. Vanrossum and colleagues, University of Groningen. "To investigate the importance of cortactin in cell migration, we downregulated its expression using RNA...
Source: Genomics & Genetics Weekly (2006-07-14)
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