Genomics & Genetics Weekly
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Allergy & Immunology
Platelets target dendritic cell differentiation and production of proinflammatory cytokines
July 14th, 2006
Intact platelets connect immunity and hemostasis by interfering with dendritic cell differentiation and cytokine production. "Dendritic cells (DCs) are the most potent antigen-presenting cells that initiate and regulate immune responses. They are unique in their feature to produce bioactive interleukin (IL)-12, a major proinflammatory cytokine connecting innate and adaptive immunity," scientists in Germany report. According to the authors, "Platelets (PLTs) are highly reactive components of the circulatory system with fundamental importance in hemostasis and innate immunity. Recently, immunomodulatory capacities of single specific human PLT-derived...
Source: Genomics & Genetics Weekly (2006-07-14)
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