Published in Genomics and Genetics Weekly, August 11th, 2006
"Chromatin condensation and oligonucleosomal DNA fragmentation are the nuclear hallmarks of apoptosis. A proteolytic fragment of the apoptotic chromatin condensation inducer in the nucleus (Acinus), which is generated by caspase cleavage, has been implicated in mediating apoptotic chromatin condensation prior to DNA fragmentation.
"Acinus is also involved in mRNA splicing and a component of the...
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