Liver Cancer
Aggressive liver cancers are defined by Met gene signatures
Published in Genomics and Genetics Weekly, August 11th, 2006
"Identification of specific gene expression signatures characteristic of oncogenic pathways is an important step toward molecular classification of human malignancies. Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis," scientists writing in the Journal of Clinical Investigation report.
"In this study, we defined the Met-dependent gene expression signature using global gene expression profiling of wild-type (WT) and Met-deficient primary mouse hepatocytes. Newly identified transcriptional targets of the Met pathway...
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