Apoptosis
Apoptosis is induced in colon cancer cells following protein dissociation
Published in Genomics and Genetics Weekly, August 11th, 2006
"PUMA is a BH3-only Bcl-2 family protein that plays an essential role in DNA damage-induced apoptosis. PUMA interacts with antiapoptotic Bcl-2 and Bcl-X-L and is dependent on Bax to induce apoptosis.
"In this study, we investigated how the interactions of PUMA with the antiapoptotic proteins coordinate with Bax to initiate apoptosis in HCT116 colon cancer cells," wrote L. Ming and colleagues, University of Pittsburgh.
"We found that Bcl-X-L was most effective among several antiapoptotic proteins in suppressing...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Genomics and Genetics Weekly
More Articles from Genomics and Genetics Weekly
- Cardiomyocytes
Contractility, calcium handling are impaired by 70-kDA heat shock protein gene deletion in mice - Diabetes Genetics & Genomics
Kir6.2 gene mutations in R50 residue cause neonatal diabetes plus different functional effects - Liver Cancer
Aggressive liver cancers are defined by Met gene signatures - Lung Cancer
Lung cancer patients carry key genetic mutations in pleural effusions - Age-Related Macular Degeneration
The risk for age-related macular degeneration is raised by complement factor H variation - Allergy & Immunology
Allergic inflammation is modified by different bacterial ligands in a rhinitis model - More from this issue of Genomics and Genetics Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
