Gene Research
Age-related macular degeneration risk is marked by complement factor-H polymorphism
Published in Genomics and Genetics Weekly, November 3rd, 2006
Researchers in India conducted a study "to screen polymorphisms in CFH, toll-like receptor 4 (TLR4), and APOE genes as potential risk factors for age-related AMD in Indian patients. One hundred patients with AMD and 120 normal control subjects were screened for the polymorphisms by restriction digestion and resequencing."
"Five intragenic SNPs in CFH were screened to generate haplotype data in cases and controls. The data were analyzed in conjunction with data from other populations based on genotype and haplotype frequencies, and odds ratios were computed to...
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