Lung Cancer
Lung cancer response to gefitinib parallels mutation patterns of epidermal growth factor receptor
Published in Genomics and Genetics Weekly, November 3rd, 2006
According to recent research from Taiwan, "Mutational analysis was performed in the kinase domain (exons 18-21) of the EGFR gene on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received gefitinib monotherapy. The association between EGFR gene mutation, gefitinib treatment response, and the overall survival were evaluated."
"In total, EGFR mutations with complex patterns were identified in 32 tumors. The overall mutation rate was 49.2% (32/65). Twenty of the 32 patients were responders, 10 non-responders, and 2 not...
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