Prostate Cancer
Prostate cancer laminin genes support signal transduction
Published in Genomics and Genetics Weekly, November 10th, 2006
"In prostate cancer progression, the basal lamina switches from predominantly laminin-5 to laminin-10. DU-145 prostate cancer cells were treated with either soluble laminin-5 (20 ng/mL) or laminin-10 (1 mcg/mL) for 6,24, and 48 hr," investigators in the United States reported.
"Total RNA was harvested for a 7,500 human cDNA microarray. Hybridizations were carried out in accordance with a 10 sample analysis of variance (ANOVA) statistical model. One thousand one hundred sixteen genes had measurable expression 2 standard deviations above background and 50% of spots for any given sample for all...
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