Cell Biology
Research from Baylor College of Medicine in cell biology provides new insights
Published in Genomics and Genetics Weekly, January 5th, 2007
Fresh data on cell biology are presented in the report "Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression." According to recent research from the United States, "The pluripotent factor Oct4 is a key transcription factor that maintains embryonic stem (ES) cell self-renewal and is down-regulated upon the differentiation of ES cells and silenced in somatic cells. A combination of cis elements, transcription factors, and epigenetic modifications, such as DNA methylation, are involved in the regulation of Oct4 gene expression."
"Here we show that the orphan nuclear receptor GCNF...
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