Genetics & Genomics
New findings from Karolinska Institute in the area of genetics & genomics described
Published in Genomics and Genetics Weekly, July 13th, 2007
New research, "Phenotype selection for detecting variable genes: a survey of cardiovascular quantitative traits and TNF locus polymorphism," is the subject of a report. "The practice of using discrete clinical diagnoses in genetic association studies has seldom led to a replicable genetic model. If, as the literature suggests, weak genotype-phenotype relationships are detected when clinical diagnoses are used, power might be increased by exploring more fundamental biological traits," investigators in Stockholm, Sweden report.
"Emerging solutions to this include directly modeling levels of the protein product of a gene (usually in plasma) and sequence variation...
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