Genetics & Genomics
Researchers from Georg-August University, Department of Clinical Pharmacology detail findings in genetics & genomics
Published in Genomics and Genetics Weekly, July 13th, 2007
Scientists discuss in "Genetic variation at the CYP2C locus and its association with torsemide biotransformation" new findings in genetics & genomics. According to a study from Germany, "In 97 unselected volunteers and two additional homozygous carriers of CYP2C9(*)3, we investigated the oral clearance of torsemide in relation to 37 polymorphisms at the CYP2C gene locus. Torsemide total oral clearance was linearly associated with the number of CYP2C9(*)3 alleles (geometric mean: 59, 40 and 20 ml/min in carriers of no, one and two alleles) and so were the methyl-and ring-hydroxylation but not the carboxylation clearance."
"Haplotypes including the CYP2C9(*)3 allele were...
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