Bone Research
Reports from Academic Medical Center advance knowledge in bone research
Published in Genomics and Genetics Weekly, July 13th, 2007
New investigation results, "Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells," are detailed in a study published in Gastroenterology. "Barrett's esophagus (BE) is a metaplastic condition in which normal squamous esophageal epithelium is replaced by columnar epithelium. It is proposed that one of the possible mechanisms is dedifferentiation of squamous epithelium into columnar epithelium," researchers in Amsterdam, Netherlands report.
"The pathophysiology through which this metaplasia occurs is unknown. A recent study by serial analysis of gene expression showed that bone morphogenetic protein 4...
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