Drug Resistance
Researchers at Imperial College target drug resistance
Published in Genomics and Genetics Weekly, July 13th, 2007
Research findings, "ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research," are discussed in a new report. According to recent research published in the The Pharmacogenomics Journal, "The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of diseases."
"It is postulated that ABCB1 polymorphisms contribute to variability in PGP function, and that therefore multidrug resistance is, at least in part, genetically determined. However, studies of ABCB1 genotype or...
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