Cystic Fibrosis

Researchers from Columbus Children's Hospital discuss findings in cystic fibrosis

Published in Genomics and Genetics Weekly, January 18th, 2008

"Surfactant-associated proteins (SP) A and D are both innate immunity mediators and produced in normal and diseased sinus mucosa. Cystic fibrosis (CF) is associated with Th1 adaptive inflammation whereas allergic fungal rhinosinusitis (AFRS) is associated with Th2 adaptive inflammation," scientists writing in the American Journal of Rhinology report.

"The purpose of this study is to show and quantify the presence of SP A, SP D, tumor necrosis factor (TNF) alpha, (a Th1 marker), and eotaxin (a Th2 marker) in normal and diseased sinus mucosa. Intraoperative sinus mucosal biopsy specimens from human volunteers were obtained during endoscopic sinus surgery for CF (n...

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Source: Genomics and Genetics Weekly (2008-01-18)

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