Human Genetics

Investigators at Carnegie Mellon University zero in on human genetics

Published in Genomics and Genetics Weekly, April 4th, 2008

According to recent research from the United States, "Resources being amassed for genome-wide association (GWA) studies include ''control databases'' genotyped with a large-scale SNP array. How to use these databases effectively is an open question."

"We develop a method to match, by genetic ancestry, controls to affected individuals (cases). The impact of this method, especially for heterogeneous human populations, is to reduce the false-positive rate, inflate other spuriously small p values, and have little impact on the p values associated with true positive loci. Thus, it highlights true positives by downplaying false positives. We perform a GWA by matching...

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Source: Genomics and Genetics Weekly (2008-04-04)

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