Genomics & Genetics Weekly
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Prostate Cancer
Findings from B.T. Larson and co-authors broaden understanding of prostate cancer
May 16th, 2008
According to recent research from the United States, "Allelic variations in the HPC1/RNASEL gene, especially the R462Q single nucleotide polymorphism, have been associated with increased susceptibility to prostate cancer. Prior studies have suggested that HPC1 or R462Q associated tumors present with more aggressive clinical features." "We assessed a series of men undergoing radical prostatectomy for clinical and pathological measures of tumor aggressiveness according to the RNASEL R462Q genotype. A prospective analysis of 232 men treated for prostate cancer with radical prostatectomy was performed. Disease aggressiveness at diagnosis was assessed by age at disease onset,...
Source: Genomics & Genetics Weekly (2008-05-16)
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