Genomics & Genetics Weekly
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Alzheimer Disease
Reports outline Alzheimer disease research from H.K. Park and colleagues
July 4th, 2008
"Although mutations in three genes, amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), have been identified as genetic causes of early-onset Alzheimer's disease (EGAD), there has been a single report on a PSEN1 mutation in Koreans. In the present study, we performed a genetic analysis of six Korean patients with EGAD," scientists in Seoul, South Korea report. "Direct sequencing analysis of the APP, PSEN1 and PSEN2 genes revealed two different mutations of the PSEN1 gene (G206S and M233T) and one mutation of the APP gene (V715M) in three patients with age-at-onset of 34, 35, and 42 yr, respectively. In addition, two patients with...
Source: Genomics & Genetics Weekly (2008-07-04)
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